abstract：BACKGROUND AND AIMS:While caloric restriction (CR) is associated with a prolonged lifespan in multiple species by regulating metabolism, a comprehensive profile of metabolism under CR conditions remains largely unclear. Therefore, in this study we aimed to characterize the metabolomic profiling associated with CR using...

journal_title：Aging clinical and experimental research

authors： Zhang Y,Yan S,Gao X,Xiong X,Dai W,Liu X,Li L,Zhang W,Mei C

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND AND AIMS:The MDS inter- RAI Acute Care is a comprehensive geriatric assessment tool for hospitalized older persons. The aim was to examine its validity based on test content by use in daily clinical practice. METHODS:Clinical staff of multiple disciplines assessed 256 older persons (83.2±5.2 years; 60% fema...

journal_title：Aging clinical and experimental research

authors： Wellens NI,Deschodt M,Boonen S,Flamaing J,Gray L,Moons P,Milisen K

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Cardiovascular disease is a major cause of mortality in end-stage renal disease patients (ESRD). The rate of elderly and polypathologic patients in ESRD is increasing. Elevated levels of C-reactive protein (CRP) have been shown to be associated with increased mortality in ESRD patients. The aim of t...

journal_title：Aging clinical and experimental research

authors： Millet C,Bosson JL,Pernod G,Wauters JP,Couturier P,Quesada JL,Zaoui P

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND AIMS:The aim of this study was to investigate superoxide dismutase (SOD) activity together with malondialdehyde (MDA) levels in a group of Chinese patients with age-related macular degeneration (AMD). METHODS:Serum SOD activity and MDA levels were analysed in 56 AMD patients with subtypes (early dry, ge...

journal_title：Aging clinical and experimental research

authors： Jia L,Dong Y,Yang H,Pan X,Fan R,Zhai L

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Squamous cell carcinoma (SCC) of the oral tongue is one of the most frequent head and neck cancers. The over-70-year age group is the fastest growing segment of the population. Age, however, is not considered a prognostic factor in oral tongue SCC. This study investigated the clinical and histopatho...

journal_title：Aging clinical and experimental research

authors： Soudry E,Preis M,Hod R,Hamzany Y,Hadar T,Bahar G,Sternov Y,Shpitzer T

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND AND AIMS:The purpose of this study was to determine the relationship between whole body energy metabolism measured as oxygen consumption (VO2) and local muscle activity measured by positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG). METHODS:Ten community- dwelling older women (73-83 yrs) h...

journal_title：Aging clinical and experimental research

authors： Shimada H,Sturnieks D,Endo Y,Kimura Y,Suzuki T,Oda K,Ishii K,Ishiwata K

更新日期：2011-06-01 00:00:00

abstract：:The incidence of acetabular fractures in the elderly is recently becoming common. Acetabular fractures in this age range are more demanding, regarding fracture patterns, poor bone quality, patient status and potential comorbidities. Therefore it is necessary to determine the ideal treatment that should allow patients ...

journal_title：Aging clinical and experimental research

authors： D'Imporzano M,Liuni FM,Tarantino U

更新日期：2011-04-01 00:00:00

abstract：:In severe osteoporosis with recent vertebral compression fracture, drug treatment with anabolic agent in the first 18 months can stimulate the healing process and reduce the rate of progression, preventing new fractures and improving the quality of life of the patient. The sequential therapy with bisphosphonates for a...

journal_title：Aging clinical and experimental research

authors： Corradini C,Malagoli E,Verdoia C

更新日期：2011-04-01 00:00:00

abstract：:Falls in the elderly are very common and represent a serious cause of morbidity, severe disability and death. Impairments of the mechanisms of postural stability with age and the presence of acute and chronic diseases may favour the occurrence of falls in the elderly. Together with the adoption of non-pharmacological ...

journal_title：Aging clinical and experimental research

authors： Gatto S,Gimigliano F,Gimigliano R,Iolascon G

更新日期：2011-04-01 00:00:00

abstract：:The current trend toward an ever increasing aging population forces society to face the problem of how to care for elderly people who are exposed to the risk of so-called "elder abuse," a phenomenon becoming increasingly widespread in Italy, as legislation does not provide a precise juridical definition of "elderly" n...

journal_title：Aging clinical and experimental research

authors： Molinelli A,Viale L,Landolfa MC,De Stefano F

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Elderly subjects are characterized by a high prevalence of chronic obstructive pulmonary disease (COPD) and frailty. This study examined the predictive role of frailty on long-term mortality in elderly subjects with and without COPD. METHODS:The study assessed mortality after a 12-year follow-up in...

journal_title：Aging clinical and experimental research

authors： Galizia G,Cacciatore F,Testa G,Della-Morte D,Mazzella F,Langellotto A,Raucci C,Gargiulo G,Ferrara N,Rengo F,Abete P

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AND AIMS:The relative weight of various etiologies of dementia and mild cognitive impairment (MCI) as predictors of intra-hospital, short- and long-term mortality in very old acutely ill patients suffering from multiple comorbid conditions remains unclear. We investigated intra-hospital, 1- and 5-year mortal...

journal_title：Aging clinical and experimental research

authors： Zekry D,Herrmann FR,Graf CE,Giannelli S,Michel JP,Gold G,Krause KH

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:The incidence and costs of acute myocardial infarction (AMI) in Europe represent a substantial problem due to population aging. METHODS:Between 2001 and 2005, Italian hospitalization records were examined to evaluate hospital admissions and costs of AMI in adults aged ≥ 45 and in elderly people ≥ 65 or ≥ 75...

journal_title：Aging clinical and experimental research

authors： Piscitelli P,Iolascon G,Greco M,Marinelli A,Gimigliano F,Gimigliano R,Gisonni P,Giordano A,Migliore A,Granata M,Tarantino U,Brandi ML,Baggiani A,Distante A

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Nitric oxide (NO) may play a critical role in facilitating the delivery of blood to active skeletal muscle, ultimately impacting functional health in older adults. Plasma nitrite is a useful marker of vascular NO bioavailability. The aim of the current investigation was to examine the effect of a wi...

journal_title：Aging clinical and experimental research

authors： Dobrosielski DA,Presley T,Perlegas A,Marsh AP,Kim-Shapiro D,Rejeski WJ

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Lumbar spinal stenosis (LSS), osteoarthritis (OA) of the knee, and osteoporosis are major locomotive diseases in the elderly population. The aim of this study was to examine the effectiveness of exercise in these three diseases. METHODS:We reviewed the relevant literature, i.e., systematic reviews ...

journal_title：Aging clinical and experimental research

authors： Iwamoto J,Sato Y,Takeda T,Matsumoto H

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Despite evidence of cognitive impairment and difficulties in performing daily activities among elderly people with major depression, studies implementing objective performance-based evaluation of functional deficits in this patient population are scarce. With the aid of a computerized device we exam...

journal_title：Aging clinical and experimental research

authors： Rosenblum S,Werner P,Dekel T,Gurevitz I,Heinik J

更新日期：2010-04-01 00:00:00

abstract：AIM:We report 3 cases of spontaneous insufficiency fracture of long bones, to promote awareness of this phenomenon to medical personnel dealing with long-term bedridden patients. METHODS:Cases were analyzed in the light of a literature review. RESULTS:Our patients were all women, who were severely debilitated and had...

journal_title：Aging clinical and experimental research

authors： Manevich D,Brill S,Hershkovitz A

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Carotid sinus hypersensitivity (CSH) is a common cause of fainting and falls in the older adult population and is diagnosed by carotid sinus massage (CSM). Previous work has suggested that age-related stiffening of blood vessels reduces afferent input from the carotid sinus leading to central upregu...

journal_title：Aging clinical and experimental research

authors： Madden KM,Lockhart C,Khan K

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Falls causing injuries among older people and the consequences of those injuries are of increasing concern to public health practitioners. The aims of this study were to determine the incidence, characteristics and risk factors of fall injuries among the community-dwelling elderly in Shihpai, Taiwan...

journal_title：Aging clinical and experimental research

authors： Chang NT,Yang NP,Chou P

更新日期：2010-02-01 00:00:00

abstract：:Despite strong evidence for the efficacy of integrated systems, securing the participation of health professionals, particularly primary care physicians (PCPs), has proven difficult. Novel approaches are needed to resolve these problems. We developed a model - COPA - that is based on scientific evidence and an origina...

journal_title：Aging clinical and experimental research

authors： Vedel I,De Stampa M,Bergman H,Ankri J,Cassou B,Mauriat C,Blanchard F,Bagaragaza E,Lapointe L

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND AIMS:As life expectancy rises worldwide and the population grows older, psychopathology in older adults becomes a significant public health concern and intervention methods acquire renewed importance. The aim of the present study was to assess the efficacy of Life Review as an intervention strategy in wo...

journal_title：Aging clinical and experimental research

authors： Gonçalves DC,Albuquerque PB,Paul C

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Nursing home residents constitute a frail, multi-diseased and heterogeneous group. As physical activity is essential for the preservation of function, personalized training and activities are of great importance. The main objective of this study was to describe the influence of an individually tailo...

journal_title：Aging clinical and experimental research

authors： Frändin K,Borell L,Grönstedt H,Bergland A,Helbostad JL,Puggaard L,Andresen M,Granbo R,Hellström K

更新日期：2009-08-01 00:00:00

abstract：:Prevention is an important but neglected issue in geriatric medicine. Vaccination plays a major role in prevention of infectious diseases, but its implementation in clinical practice is far from perfect. To improve practice, a group of French experts composed of geriatricians and infectious disease specialists prepare...

journal_title：Aging clinical and experimental research

authors： Belmin J,Bourée P,Camus D,Guiso N,Jeandel C,Trivalle C,Veyssier P

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Marital and parental role characteristics are important factors in both men and women's health. Most studies to date have either focused on disease specific outcomes or summary measures of self-reported health rather than using functional tests of performance. The goal of this study is to investigat...

journal_title：Aging clinical and experimental research

authors： Guralnik JM,Butterworth S,Patel K,Mishra G,Kuh D

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND AIMS:In response to surgical stress, the body reacts with a change in metabolism to a catabolic state. This is further aggravated by the fasting state preoperatively. We aimed to determine the effects on catabolism i.e., body composition and IGF-I bioavailability as measured by the serum IGF-I/IGFBP-1 ra...

journal_title：Aging clinical and experimental research

authors： Aronsson A,Al-Ani NA,Brismar K,Hedström M

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND AIMS:The effect of heavy work-related physical loads (WRPL) on low back pain (LBP) and impaired physical function has been studied extensively in active workers but not in pensioners. METHODS:We compared LBP and physical function in post-menopausal pensioners, divided according to their life-long WRPL i...

journal_title：Aging clinical and experimental research

authors： Gnudi S,Sitta E,Gnudi F,Pignotti E

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND AIMS:To evaluate the effect of interdisciplinary outpatient geriatrics on the use, cost, and quality of health services in a fee-for-service (FFS) environment of two networks of primary care clinics operated by a not-for-profit provider organization in Dallas County, Texas. METHODS:The Senior Health Net...

journal_title：Aging clinical and experimental research

authors： Famadas JC,Frick KD,Haydar ZR,Nicewander D,Ballard D,Boult C

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND AND AIMS:In order to investigate the relation between personal functional capacity and the physical housing environment during the aging process, the aim of this study was to give a long-term description of person-environmental fit (P-E fit) problems in terms of housing accessibility and ADL dependence among...

journal_title：Aging clinical and experimental research

authors： Werngren-Elgström M,Carlsson G,Iwarsson S

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND AND AIMS:The aim of this study was to develop a Turkish version of the Nottingham Extended Activities of Daily Living Scale (NEADLS) and to assess its reliability and validity. METHODS:Sixty healthy volunteers over 67 years old were included in the study. After translation, the Turkish version of the scale ...

journal_title：Aging clinical and experimental research

authors： Sahin F,Yilmaz F,Ozmaden A,Kotevoglu N,Sahin T,Kuran B

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Although the role of afferent input from cervical muscles on the control of posture and locomotion is recognised, it is surprising that there is an absence of data reporting whether joint position sense at the cervical level is impaired in older healthy adults. The present experiment was designed to...

journal_title：Aging clinical and experimental research

authors： Vuillerme N,Pinsault N,Bouvier B

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Low total lymphocyte count (TLC) has been found to be a poor prognostic factor in adults affected by heart diseases, malignancy, and renal failure. The aims of this study were to verify if a low TLC was associated with in-hospital mortality in older persons and to evaluate whether this association w...

journal_title：Aging clinical and experimental research

authors： Marengoni A,Petroboni B,Casella S,Martinelli D,Cossi S

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Changes in sensory- motor systems that occur with age result in a decrease in postural equilibrium, which has been linked with an increased risk of falling in the elderly. Stepping down backwards from a step perturbs dynamic postural equilibrium, thus offering an opportunity to analyze the biomechan...

journal_title：Aging clinical and experimental research

authors： Michel-Pellegrino V,Hewson D,Hogrel JY,Duchêne J

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Functional brain imaging has shown that bilateral brain reorganization may occur after unilateral cerebral damage. The present study searched for evidence of bilateral motor control changes in gait in patients with chronic unilateral stroke. METHODS:Gait variables (temporal and spatial parameters, ...

journal_title：Aging clinical and experimental research

authors： Titianova EB,Peurala SH,Pitkänen K,Tarkka IM

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Proximal femoral fracture is often associated with long-term residual disability. Quadriceps weakness may be a factor in poor outcome. This study aimed to determine whether training of the quadriceps using electrical stimulation (ES) increases leg extensor power and decreases disability in elderly s...

journal_title：Aging clinical and experimental research

authors： Braid V,Barber M,Mitchell SL,Martin BJ,Granat M,Stott DJ

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Monochromatic pulsating light may have effects on wound healing. In an earlier study of grade II ulcers, there was a tendency toward better healing in the phototherapy group (p=0.06). The present study on patients with grade II ulcers was performed to verify these findings. Data from this study were...

journal_title：Aging clinical and experimental research

authors： Dehlin O,Elmståhl S,Gottrup F

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Peptydil prolyl cis-trans isomerase (PIN-1), which specifically regulates the conformational changes following phosphorylation of several proteins, targets the inactive hyper-phosphorylated tau on the Thr231-Pro motif and directly restores its biological function. Interestingly, PIN-1 is oxidatively...

journal_title：Aging clinical and experimental research

authors： Arosio B,Segat L,Milanese M,Galimberti L,Calabresi C,Zanetti M,Trabattoni D,Annoni G,Crovella S,Vergani C

更新日期：2007-10-01 00:00:00

abstract：:The patient, a 79-year-old woman with a history of osteoporosis, presented with acute back pain without trauma, three years ago. Spinal X rays showed a vertebral compression fracture at T7, and DXA indicated a T-score of -2.65 BMD at the total hip. The patient started treatment with alendronate 70 mg once a week, plus...

journal_title：Aging clinical and experimental research

authors： Resmini G,Iolascon G

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND AND AIMS:An accurate diagnosis of sarcopenia is required. The aim of this study is to correlate the results of two methods to define sarcopenia using cross sectional body composition data, with actual loss of fat free mass. METHODS:Healthy older subjects (926 females and 381 males aged 70 years or more) and...

journal_title：Aging clinical and experimental research

authors： Bunout D,de la Maza MP,Barrera G,Leiva L,Gattas V,Hirsch S

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Acetylcholinesterase inhibitor (AChEis) therapy in Alzheimer Disease (AD) has been shown to provide cognitive benefits and to slow progression of the disease. AChEis have also been demonstrated to improve behavioral symptoms, although there seem to be subtle differences in the magnitude of response....

journal_title：Aging clinical and experimental research

authors： Rozzini L,Vicini Chilovi B,Bertoletti E,Trabucchi M,Padovani A

更新日期：2007-06-01 00:00:00

abstract：:Visual identification of vertebral fractures from spinal radiographs makes use of operator expertise in ruling out non-fracture deformities or normal variants. Morphometric X-ray absorptiometry (MXA) has recently been developed to assess vertebral deformity status quantitatively by dual energy X-ray absorptiometry (DX...

journal_title：Aging clinical and experimental research

authors： Francucci CM,Romagni P,Fiscaletti P,Caudarella R,Boscaro M

更新日期：2007-06-01 00:00:00